Two legs, total goals; home team listed first.
Real Madrid vs. Galatasaray
| Apr. 3– | Galatasaray 3 | Real Madrid 2 |
| Apr. 18– | Real Madrid 3 | Galatasaray 0 |
| Real Madrid wins 5-3 on aggregate |
Bayern Munich vs. Manchester United
| Apr. 3– | Manchester United 0 | Bayern Munich 1 |
| Apr. 18– | Bayern Munich 2 | Manchester United 1 |
| Bayern Munich wins 3-1 on aggregate |
Arsenal vs. Valencia
| Apr. 4 | Arsenal 2 | Valencia 1 |
| Apr. 17 | Valencia 1 | Arsenal 0 |
| Valencia wins on away goals |
Leeds United vs. Deportivo la Coruna
| Apr. 4 | Leeds United 3 | Deportivo la Coruna 0 |
| Apr. 17 | Deportivo la Coruna 2 | Leeds United 0 |
| Leeds United wins 3-2 on aggregate |
2000-01 Champions League Second Group Phase 2000-01 Champions League 2000-2001 Champions League Semifinals 
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