Frank, Joachim, 1940–, German-American physicist and biochemist, b. Siegen, Germany, Ph.D., Technical Univ. of Munich 1970. He became a U.S. citizen in 1997. Following several postdoctoral appointments, Frank joined the New York State Department of Health as a researcher in 1977. From 1977 to 2003, he was a professor at the State Univ. of New York at Albany. In 2003, he joined the faculty at Columbia. With Jacques Dubochet and Richard Henderson , Frank was awarded the Nobel Prize in Chemistry in 2017 for work in developing cryo-electron microscopy, which permits the high-resolution determination of the structure of biomolecules in solution. Between 1975 and 1986, Frank developed a digital analysis technique that merged previously fuzzy two-dimensional images generated using electron microscopy to produce images that revealed clear three-dimensional structures. Frank has used his cryo-electron microscopy to study how cell ribosomes interact with other molecules.
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