Apurímac apo͞orē´mäk [key], river, c.430 mi (690 km) long, rising in the Andes, S Peru. It flows generally northwest in a narrow valley. After joining the Mantaro River, the Apurímac becomes the Ene; after joining the Perené River, it becomes the Tambo. When it joins the Urubamba River, it becomes the Ucayali , which is one of the main headstreams of the Amazon . The headwaters of the Apurímac, which rise from glacial meltwater on Nevado Mismi, were determined by a 2000 expedition to the most distant from the mouth of the Amazon.

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