The master gland, i.e., the gland that regulates many of the other endocrine glands, is the pituitary, located at the base of the brain. Also called the hypophysis, the pituitary secretes at least five hormones that directly affect the other endocrine glands. It secretes thyrotropin, which manages thyroid gland activity, adrenocorticotropic hormone (ACTH), which regulates activity of the adrenal cortex, and three gonadotropic hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and luteotropic hormone (LTH), all of which control the growth and reproductive activities of the sex glands. The pituitary also produces substances that do not act directly on other endocrine glands: somatotropic hormone, or growth hormone, which controls growth in all tissues; antidiuretic hormone (ADH), which controls the rate of water excretion in the urine; oxytocin, which stimulates uterine contraction and helps regulate milk production by the breasts; and melanocyte-stimulating hormone, which regulates the activity of the melanocytes, or pigment-producing cells.
The adrenal gland is another endocrine gland regulated by the pituitary. The adrenal cortex, the outer part of each of the two adrenal glands, produces aldosterone, cortisol, and other steroids. These substances regulate salt concentration in body fluids and glucose, fat, and protein metabolism. The inner portion of the gland, the adrenal medulla, secretes epinephrine (adrenaline) and norepinephrine, substances connected with the autonomic nervous system that help the body to respond to danger or stress.
The thyroid, located below the larynx and partially surrounding the trachea, produces thyroxine, which controls the metabolic rate of most body cells, and calcitonin, which is responsible for maintaining proper calcium serum levels in the body.
The testes produce the male sex hormone testosterone, which controls the development of the male sex organs as well as secondary sex characteristics. The pituitary hormone LH regulates testosterone production, and FSH initiates sperm formation in the testes. In females, FSH, LH, and LTH are integrated into the complex monthly cycles of ovulation, production of the hormones estrogen and progesterone by the ovaries and corpus luteum, and menstruation; LTH also contributes to lactation. Estrogen controls growth of the sex organs and breasts and regulates secondary sex characteristics. The most important function of progesterone is to prepare the uterine lining for implantation of a fertilized egg.
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