Breadcrumb Home > Dictionary > Index P pisser: Meaning and Definition of Find definitions for: piss•er Pronunciation: (pis'ur), [key] — n. Slang (vulgar) something extremely difficult or unpleasant. something or someone that is extraordinary. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: pisser (Thesaurus) pissed off pissoir* ✖ Related Content Daily Word Quiz: cacophony Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language