Breadcrumb Home > Dictionary > Index M methotrexate: Meaning and Definition of Find definitions for: meth•o•trex•ate Pronunciation: (meth"ō-trek'sāt), [key] — n. Pharm. a toxic folic acid analogue, CHNO, that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: methotrexate (Thesaurus) methoprene methought TrendingHere are the facts and trivia that people are buzzing about. Animal Group Terminology Largest Countries in the World (by Area) Current Events This Week: January 2023 State Abbreviations Dinosaur Fossils (By U.S. State!) The Chinese Zodiac ✖ Related Content Daily Word Quiz: locution Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language