Breadcrumb Home > Dictionary > Index L Cite loco: Meaning and Definition of Find definitions for: lo•co Pronunciation: (lō'kō), [key] — n., pl. v., adj. -cos, -coed, -co•ing, —n. locoweed. an insane person; maniac. locoism. —v.t. to poison with locoweed. to cause to be insane or crazy. —adj. out of one's mind; insane; crazy. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: loco (Thesaurus) Lockyer loco citato* TrendingHere are the facts and trivia that people are buzzing about. January 2021 Current Events: US News Noble Titles and Ranks in a Monarchy Chinese New Year History, Meaning, and Celebrations The Manchu Keeping Your Brain Active in a COVID-19 World Inaugural Trivia Related Content Daily Word Quiz: evanescent Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language