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Meaning of loco

lo•co

Pronunciation: (lō'kō), [key]
— n., pl. v., adj. -cos, -coed, -co•ing,
—n.
  1. locoweed.
  2. an insane person; maniac.
  3. locoism.
—v.t.
  1. to poison with locoweed.
  2. to cause to be insane or crazy.
—adj.
  1. out of one's mind; insane; crazy.
Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
See also:
Lockyer loco citato*