Breadcrumb Home > Dictionary > Index C chronic fatigue syndrome: Meaning and Definition of Find definitions for: chron'ic fatigue' syn"drome Pronunciation: [key] a viral disease of the immune system, usu. characterized by debilitating fatigue and flu-like symptoms. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. chronic chronic glaucoma, ✖ Related Content Daily Word Quiz: hieratic Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language