Breadcrumb Home > Dictionary > Index B botheration: Meaning and Definition of Find definitions for: both•er•a•tion Pronunciation: (bo"u-rā'shun), [key] — interj. (used as an exclamation indicating vexation or annoyance.) —n. the act or state of bothering or the state of being bothered. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: botheration (Thesaurus) bother bothersome ✖ Related Content Daily Word Quiz: derogate Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language