San Franciscosăn frănsĭs´kō [key], city (1990 pop. 723,959), coextensive with San Francisco co., W Calif., on the tip of a peninsula between the Pacific Ocean and San Francisco Bay, which are connected by the strait known as the Golden Gate; inc. 1850. The city is the heart of the San Francisco Bay region and with Oakland and San Jose comprises the fourth largest metropolitan area in the United States.
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