Breadcrumb Home > Dictionary > Index O Cite Opechancanough: Meaning and Definition of Find definitions for: O•pech•an•ca•nough Pronunciation: (?-pech"un-k'n?), [key] ? n. c1545?1644, Algonquian leader, brother of Powhatan: led Jamestown massacre 1622. Random House Unabridged Dictionary, Copyright 1997, by Random House, Inc., on Infoplease. OPEC Op-Ed TrendingHere are the facts and trivia that people are buzzing about. February 2021 Current Events: US News The Berlin Conference and the Partition of Africa The Implied Powers of Congress Noble Titles and Ranks in a Monarchy Keeping Your Brain Active in a COVID-19 World The Manchu Related Content Daily Word Quiz: nosegay Analogy of the Day: Today?s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language