Breadcrumb Home > Dictionary > Index L lobotomy: Meaning and Definition of Find definitions for: lo•bot•o•my Pronunciation: (lu-bot'u-mē, lō-), [key] — pl. -mies. the operation of cutting into a lobe, as of the brain or the lung. See Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: lobotomy (Thesaurus) lobotomized lobscouse TrendingHere are the facts and trivia that people are buzzing about. Biographies: Notable Jewish Religious Leaders Current Events This Week: September 2023 Hispanic Population and the 2010 U.S. Census Preamble of the United Nations Charter The Jewish Calendar ✖ Related Content Daily Word Quiz: bildungsroman Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language