Meaning of alienation

al•ien•a•tion

1. the act of alienating.
2. the state of being alienated.
3. a transfer of the title to property by one person to another; conveyance.
4. the state of being withdrawn or isolated from the objective world, as through indifference or disaffection.
5. the lack of correlation in the variation of two measurable variates over a population.