Several genes that signal a hereditary predisposition to colon cancer have been identified. For example, mutations in either of two genes, MSH2 and MLH1, can predispose a person to hereditary nonpolyposis colorectal cancer (HNPCC). People in HNPCC families can undergo blood tests that can tell them whether they have an affected gene. With the information obtained from such screening, an appropriate course of preventive measures and follow-up tests can be initiated (see genetic testing).
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