Yamasee, Yamasi both: yăm´əsē, yäm´– [key], or Yemasee yĕm´– [key], Native North Americans whose language belongs to the Muskogean branch of the Hokan-Siouan linguistic stock (see Native American languages ). In the late 16th cent., when Spanish missions were established among them, the Yamasee lived in S Georgia and N Florida. They remained under Spanish rule until 1687, when they revolted and fled to South Carolina. The Yamasee were initially friendly toward the English, but in 1715 war broke out and they massacred more than 200 white settlers. Driven out of South Carolina, the Yamasee returned to Florida, where they became allies of the Spanish against the English. In 1727 their village near St. Augustine was attacked and destroyed by the English. Their population declined, and eventually they assimilated with the Seminole and the Creek .
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