Meaning of softening of the brain

soft'ening of the brain'

Pronunciation: [key]
— Pathol. Pathol.
  1. a softening of the cerebrum, caused by impairment of the blood supply; encephalomalacia.
  2. dementia associated with general paresis.
Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.