Breadcrumb Home > Dictionary > Index P Cite painkiller: Meaning and Definition of Find definitions for: pain•kill•er Pronunciation: (pān'kil"ur), [key] a drug, treatment, or anything else that relieves pain, esp. an analgesic. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: painkiller (Thesaurus) painful painless TrendingHere are the facts and trivia that people are buzzing about. January 2021 Current Events: US News The Holocaust (1933–1945) Chinese New Year History, Meaning, and Celebrations Noble Titles and Ranks in a Monarchy The 5 Best Air Purifiers of 2020 Inaugural Trivia Related Content Daily Word Quiz: jerrybuilt Analogy of the Day: Today’s Analogy Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language