| First Round—Austin | Eastern Kentucky 64, Kentucky 72 |
| Iowa 64, Cincinnati 76 |
| Niagara 67, Oklahoma 84 |
| Texas-El Paso 54, Utah 60 |
| Vermont 60, Syracuse 57 |
| Delaware State 46, Duke 57 |
| Old Dominion 81, Michigan State 89 |
| Mississippi State 93, Stanford 70 |
| First Round—Albuquerque | Pittsburgh 71, Pacific 79 |
| Montana 77, Washington 88 |
| Chattanooga 54, Wake Forest 70 |
| Winthrop 64, Gonzaga 74 |
| Creighton 61, West Virginia 63 |
| UCLA 66, Texas Tech 78 |
| George Washington 68, Georgia Tech 80 |
| Louisiana-Lafayette 62, Louisville 68 |
| First Round—Chicago | Pennsylvania 65, Boston College 85 |
| Nevada 61, Texas 57 |
| Utah State 53, Arizona 66 |
| Fairleigh Dickinson 55, Illinois 67 |
| Univ. of Ala.-Birmingham 82, Louisiana State 68 |
| Wisconsin-Milwaukee 83, Alabama 73 |
| St. Mary's 56, Southern Illinois 65 |
| Southeastern Louisiana 50, Oklahoma State 63 |
| First Round—Syracuse | North Carolina State 75, Charlotte 63 |
| Iowa State 64, Minnesota 53 |
| Central Florida 71, Connecticut 77 |
| Northern Iowa 52, Wisconsin 57 |
| Bucknell 64, Kansas 63 |
| Ohio 62, Florida 67 |
| New Mexico 47, Villanova 55 |
| Oakland 68, North Carolina 96 |
| Second Round—Austin | Oklahoma 58, Utah 67 |
| Cincinnati 60, Kentucky 69 |
| Vermont 61, Michigan State 72 |
| Mississippi State 55, Duke 63 |
| Second Round—Albuquerque | Gonzaga 69, Texas Tech 71 |
| West Virginia 111, Wake Forest 105 |
| Washington 97, Pacific 79 |
| Georgia Tech 54, Louisville 76 |
| Second Round—Chicago | Illinois 71, Nevada 59 |
| Boston College 75, Wisconsin-Milwaukee 83 |
| Arizona 85, Univ. of Ala.-Birmingham 63 |
| Southern Illinois 77, Oklahoma State 85 |
| Second Round—Syracuse | North Carolina State 65, Connecticut 62 |
| Bucknell 62, Wisconsin 71 |
| Villanova 76, Florida 65 |
| Iowa State 65, North Carolina 92 |
| Third Round—Austin | Michigan State 78, Duke 68 |
| Utah 52, Kentucky 62 |
| Third Round—Albuquerque | Louisville 93, Washington 79 |
| West Virginia 65, Texas Tech 60 |
| Third Round—Chicago | Wisconsin-Milwaukee 63, Illinois 77 |
| Arizona 79, Oklahoma State 78 |
| Third Round—Syracuse | North Carolina State 56, Wisconsin 65 |
| Villanova 66, North Carolina 67 |
| Regional Finals | Austin—Michigan State 94, Kentucky 88 |
| Albuquerque—West Virginia 85, Louisville 93 |
| Chicago—Arizona 89, Illinois 90 |
| Syracuse—Wisconsin 82, North Carolina 88 |
| Final Four | (April 2, 2005, St. Louis, Mo.) |
| Louisville 57, Illinois 72 |
| Michigan State 71, North Carolina 87 |
| National Final | (April 4, 2005, St. Louis, Mo.) |
| North Carolina 75, Illinois 70 |
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