The Drama Desk, a group of 150 theater critics and reporters, announced the awards on May 22, 2005.
| Outstanding Play | Doubt |
| Outstanding Musical | Monty Python's Spamalot |
| Outstanding Musical Revival | La Cage aux Folles |
| Outstanding Play Revival | Twelve Angry Men |
| Best Actor in a Play | Brian F. O'Byrne, Doubt |
| Best Actress in a Play | Cherry Jones, Doubt |
| Best Featured Actor in a Play | Michael Stuhlbarg, The Pillowman |
| Best Featured Actress in a Play | Adriane Lenox, Doubt |
| Best Actor in a Musical | Norbert Leo Butz. Dirty Rotten Scoundrels |
| Best Actress in a Musical | Victoria Clark, The Light in the Piazza |
| Best Featured Actor in a Musical | Denis O'Hare, Sweet Charity |
| Best Featured Actress in a Musical | Jan Maxwell, Chitty Chitty Bang Bang |
| Best Director of a Play | Doug Hughes, Doubt |
| Best Director of a Musical | James Lapine, The 25th Annual Putnam Country Spelling Bee |
| Best Choreography | Jerry Mitchell, La Cage aux Folles |
| Best Book of a Musical | Rachel Sheinkin, The 25th Annual Putnam Country Spelling Bee |
| Best Music | Adam Guettel, The Light in the Piazza |
| Best Lyrics | Eric Idle, Monty Python's Spamalot |
| Outstanding Orchestrations | Ted Sperling, Adam Guettel, Bruce Coughlin, The Light in the Piazza |
| Outstanding Set Design of a Play | Santo Loquasto, Glengarry Glen Ross |
| Outstanding Set Design of a Musical | Michael Yeargan, The Light in the Piazza |
| Outstanding Costume Design | Tim Hatley, Monty Python's Spamalot |
| Outstanding Lighting Design | Christopher Akerlind, The Light in the Piazza |
| Outstanding Sound Design | Paul Arditti, The Pillowman |
| Outstanding Solo Performance | Billy Crystal, 700 Sundays |
| Unique Theatrical Experience | Slava's Snowshow |
| Outstanding Ensemble Performances | Cast of Glengarry Glen Ross and cast of The 25th Annual Putnam County Spelling Bee |
| Career Achievement | Julie Harris |
| Special Awards | Keen Company and The Public Theater |
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