The tenth annual MTV Movie Awards were presented June 2, 2001.
| Best Movie | Gladiator |
| Best Male Performance | Tom Cruise, Mission: Impossible 2 |
| Best Female Performance | Julia Roberts, Erin Brockovich |
| Best Comedic Performance | Ben Stiller, Meet the Parents |
| Best Onscreen Team | Drew Barrymore, Cameron Diaz, and Lucy Liu, Charlie's Angels |
| Best Breakthrough Male Performance | Sean Patrick Thomas, Save the Last Dance |
| Best Breakthrough Female Performance | Erika Christensen, Traffic |
| Best Villain | Jim Carrey, Dr. Seuss' How the Grinch Stole Christmas |
| Best Kiss | Julia Stiles and Sean Patrick Thomas, Save the Last Dance |
| Best Action Sequence | Motorcycle chase, Mission: Impossible 2 |
| Best Fight | Zhang Ziyi vs. Entire Bar, Crouching Tiger, Hidden Dragon |
| Best New Filmmaker | Sofia Coppola, The Virgin Suicides |
| Best Music Moment | Piper Perabo sings “One Way or Another,” Coyote Ugly |
| Best Line | “Are you a pothead, Focker?” said by Robert De Niro, Meet the Parents |
| Best Cameo | James Van Der Beek, Scary Movie |
| Best Dressed | Jennifer Lopez, The Cell |
| Best Dance Sequence | Cameron Diaz, Charlie's Angels |
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