May 6, Natchez, Miss.: tornado struck heart of the city, killing 317 and injuring over 1,000.
Feb. 19, Miss., Ala., N.C., S.C., Tenn., Ky., Ind.: series of 60 tornadoes caused estimated 800 deaths.
April 24–25, La., Miss., Ala., Ga.: 18 tornadoes resulted in 310 deaths (143 of these caused by 1 tornado that moved from Amite, La. to Purvis, Miss.).
March 18, Mo., Ill., Ind.: the “Tri-State Tornado” was the most violent single twister in U.S. history. It caused the deaths of 695 people and injured over 2,000. Property damage was estimated at $16.5 million.
March 21–22, Ala., Miss., Ga., Tenn.: outbreak of 33 tornadoes killed 334 (268 in Ala.).
April 3–4: a series of 148 twisters within 16 hours comprised the deadly “Super Tornado Outbreak” that struck 13 states in the East, South, and Midwest. Before it was over, 330 died and 5,484 were injured in a damage path covering more than 2,500 mi.

Worst United States Disasters