Not inclined toward academic studies, Wayne became a surveyor in 1763. In 1765 he was engaged to survey the land for, and promote the settlement of, a proposed colony in Nova Scotia, a venture from which he withdrew in 1766. He returned to the business of farming and tanning at Waynesborough, on the farm that his grandfather had established and that he inherited. He represented Chester co. in the Pennsylvania assembly (1774–75), was an agitator against British policies, and was active in preparations to defend the cause of the colonists.
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