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Sick as a Horse
Nausea unrelieved by vomiting. A horse is unable to
vomit, because its diaphragm is not a complete partition in the
abdomen, perforated only by the gullet, and against which the stomach
can be compressed by the abdominal muscles, as is the case in man.
Hence the nausea of a horse is more lasting and more violent. (See Notes and Queries, C.S. xii., August 15th, 1885, p. 134.)
Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894 More on Sick as a Horse from Infoplease:
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