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Poison
It is said that poisons had no effect on Mithridates, King of
Pontus. This was Mithridates VI., called the Great, who succeeded his
father at the age of eleven, and fortified his constitution by drinking
antidotes to poisons which might at any moment be administered to him
by persons about the court. (See Aqua Tofana.)
Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894 More on Poison from Infoplease:
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