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Acme

Ac′me

The crisis of a disease. Old medical writers used to divide the progress of a disease into four periods: the ar-che, or beginning; the anabasis, or increase, the acme, or term of its utmost violence, and the pa-rac-me, or decline. Figuratively, the highest point of anything.

Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894
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