Mister Ed

The TV comedy Mr. Ed ran on the CBS network from 1961 to 1966. The title star was a cantankerous talking horse who would speak only to his owner, Wilbur Post, and played dumb when anyone else was present. Naturally, this created comical troubles for Wilbur (played by actor Alan Young). Mr. Ed was played by a trained show horse named Bamboo Harvester; his voice was provided by veteran actor Allan "Rocky" Lane.

Extra credit: Ed is sometimes compared to Francis the Talking Mule, the star of a movie series which ran from 1949 to 1956.