The Answer:
In early episodes, old friends of Wilma remember her as "Wilma
Pebble." On the other hand, later episodes establish her mother as
being "Mrs. Slaghoople." This presents two possibilities: either
Wilma's maiden name was Pebble, but her mother got remarried to a Mr.
Slaghoople somewhere along the way; or the early episodes are to be
ignored and Wilma's maiden name is now officially Slaghoople.
Spinoff series and the Flintstones movies accept Slaghoople as
being Wilma's maiden name.
As for Betty Rubble, her maiden name was McBricker in the TV
series, but it was changed to O'Shale for the 2000 live-action movie
The Flintstones in Viva Rock Vegas.
You might be interested in our biography of Fred
Flintstone, and our collection of Biographies of Animated
Characters and their Creators.
—The Editors
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